The chemical compound fluoxetine belongs to the group of serotonin reuptake inhibitors. Fluoxetine is most commonly used in the treatment of depressive disorders, which significantly reduce sexual desire. Fluoxetine was also used in the treatment of bulimia and bipolar disorder.

Fluoxetine - action

Fluoxetine works by inhibiting serotonin reuptake by inhibiting the serotonin transporter. It has an antagonistic effect on the release of noradrenaline and dopamine. It is also referred to as noradrenaline and dopamine disinhibitor. The clinical significance of this compound is not fully known. It has been hailed as a mood-enhancing pill by many specialists.

Fluoxetine is mainly digested in the liver, the drug is very well absorbed. Food does not affect the bioavailability of the drug. Maximum serum concentration is reached after 6-8 hours of administration.

The most frequently mentioned side effects in taking this compound are: tiredness, sleep disorders, sweating, alopecia, fever, dry mouth, gastrointestinal disorders, weakness of muscle strength, frequent headaches and dizziness, reduced libido and urination disorders, aggressive behaviour, allergies, rash, decreased appetite, weight loss, hallucinations, panic attacks, psychomotor anxiety and others.

Equally importantly, fluoxetine can adversely affect the ability to drive and operate vehicles and machines.

Fluoxetine - contraindications

The contraindication for the use of fluoxetine is the concomitant use of drugs with MAO inhibitors, some phenothiazine derivatives and other drugs. Equally importantly, the use of fluoxetine and St. John's wort extract can contribute to the formation of serotonergic effects. Fluoxetine should not be taken during pregnancy or lactation. Strict physician control will be necessary if you are taking this medicine in people with manic conditions, heart disease or if you are taking medication that affects platelet function.

Fluoxetine - indications

The main indications for administration of this compound are depressive disorders in adults, obsessive-compulsive disorders, bulimia and moderate depressive episodes. The drug is administered orally. Fluoxetine should be discontinued gradually to avoid the development of withdrawal symptoms. Be particularly careful when using this medicine.